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KMID : 0358420090520010068
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Korean Journal of Obstetrics and Gynecology
2009 Volume.52 No. 1 p.68 ~ p.74
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Ultrasound-guided Local injection of potassium chloride (KCl) and methotrexate (MTX) in the treatment of cornual pregnancy
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Park Hea-Ree
Moon Myoung-Jin
Sin Seung-Joo
Chang Sung-Woon
Ahn Eun-Hee
Jung Sang-Hee
Shim Sung-Shin
Kang Suk-Ho
Kim Hyun-Chul
Hwang Youn-Yeung
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Abstract
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Objective: To evaluate efficacy and safety of local injection of potassium chloride (KCl) and methotrexate (MTX) in the treatment of cornual pregnancy.
Methods: We retrospectively reviewed all cases of cornual pregnancy treated conservatively from 2005 through August 2007. Eight cases were identified and two cases were heterotopic interstitial pregnancy. All cases were managed with local injection of KCl or methotrexate under ultrasound guidance and 2 cases were treated with intra-muscular injection of MTX in combination. After the procedure all cases with cardiac activity was confirmed to be aborted by ultrasound. Also serial follow-up sonographic examination and serum β-hCG measurement were performed.
Results: The mean initial β-hCG level was 53,331.6 mIU/mL and ranged from 14,332 mIU/mL to 125,721 mIU/mL. Mean gestational age was 48.3 days from 40 to 65 days. All cases were aborted successfully and follow up β-hCG were declined abruptly. Two cases of heterotopic pregnancy resulted in successful deliveries at full term.
Conclusion: Cornual resection or hysterectomy should no longer be the first line of treatment for hemodynamically stable patients with cornual pregnancy. They can be successfully treated through local injection of MTX or KCl by ultrasound guidance.
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KEYWORD
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Cornual pregnancy, Heterotopic pregnancy, Ultrasound guidance, Local injection
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